Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Feronia elephantum (Corr) Fruit Pulp Extract on Indomethacin-induced Gastric Ulcer in Albino Rats

Anurag Mishra , Sandeep Arora, Rajiv Gupta, . Manvi, Rajesh Kumar Punia, Ashish Kumar Sharma

Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology & Management, Sector I, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow, U.P.-227105, India;

For correspondence:- Anurag Mishra Email: anupriya0522@yahoo.co.in Tel:+919335288099

Received: 30 January 2009 Accepted: 30 September 2009 Published: 21 December 2009

Citation: Mishra A, Arora S, Gupta R, Manvi ., Punia RK, Sharma AK. Effect of Feronia elephantum (Corr) Fruit Pulp Extract on Indomethacin-induced Gastric Ulcer in Albino Rats. Trop J Pharm Res 2009; 8(6):509-514 doi: 10.4314/tjpr.v8i6.5

© 2009 The authors.
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Abstract

Purpose: To investigate the activity of Feronia elephantum fruit pulp extract (which is used in folk medicine) against indomethacin-induced gastric ulcer in rats.

Methods: The fruit pulp was extracted with ethanol and the anti-ulcer activity of the extract in indomethacin-induced gastric ulceration in Swiss albino rats was evaluated. The parameters assessed were pH and acid concentration of gastric contents, and gastric ulcer index. Ranitidine was used as the reference anti-ulcer drug. Acute toxicity studies were also carried out.

Results: The extract (500 mg/kg, p.o.) inhibited indomethacin-induced gastric ulceration by decreasing acid concentration of gastric fluid while elevating its pH (p < 0.01), and compared well with the standard drug, ranitidine (p < 0.001). However, its anti-ulcer activity was not as potent as that of ranitidine. Acute toxicity studies showed that there was no mortality following the administration of the extract in a dose range of 250 - 5000 mg/kg, p.o.

Conclusion: Feronia elephantum fruit pulp extract has potent antiulcer activity with low toxicity. Its anti-ulcer property probably acts via a reduction in gastric acid secretion. The results obtained support the use of this herbal material in folk medicine.

Keywords: Anti-ulcer; Feronia elephantum (Corr.); Indomethacin; Ulcer; Gastric acidity